Cell cycle control in the kidney
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Full Reviews Cell cycle control in the kidney
Proper control of the cell cycle is mandatory during homeostasis and disease. The balance of p53 and MDM2 integrates numerous signalling pathways to regulate the cell cycle, which is executed by multiple proteins including the cyclins, cyclin kinases and cyclin kinase inhibitors. Mutations or environmental factors that affect cell cycle control can lead to inappropriate hyperplasia or cancer as...
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During the development of multicellular organisms, many different cell types are created. These display characteristic cell cycle programs that can radically change during the organism’s lifetime (Jakoby and Schnittger, 2004; Fig. 1). Usually, in younger and less differentiated tissues, a proliferative cell cycle mode occurs. In this mitotic cell cycle program, DNA replication (also known as th...
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gression by inhibiting cyclin–CDK complex activities. Cell Cycle Control Thus one cell cycle step is dependent on the next, not Edited by Christopher J. Hutchison because of a product-substrate relationship, but beand David Glover cause of regulatory circuits that act through the cyclin– New York: IRL Press at Oxford University Press. (1995). CDK’s. All these aspects of cell cycle regulation by...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2014
ISSN: 0931-0509,1460-2385
DOI: 10.1093/ndt/gfu395